The Met Office issued two warnings for snow and ice on Thursday.
It covers North Wales and North West Shropshire from 08:00 GMT to 15:00, and the Peak District and the South Pennines from 12:00 to 18:00.
Snowfall is expected to range between 10 and 15 cm (4-6 inches) across warning areas, and up to 25 cm (10 inches) on higher ground.
“Continuous and at times heavy” snow is expected to fall in the morning before tapering off later that day.
The Met Office said travel disruption was expected.
She warned that “it is best not to drive in these conditions”, but if people need to make an essential trip, they should consider alternative forms of transport.
In north Wales and northwest Shropshire – which is covered by a snow and ice warning – road delays and disruption to rail travel are likely.
Power outages are likely, and there is a good chance some rural communities will be temporarily out of power.
The Met Office warns that untreated pavements and cycle paths are likely to be impassable, with injuries likely from slips and falls on icy surfaces.
Strong easterly winds may also cause some snow to fall.
Similar disturbance is expected in the Peak District and South Pennines, where a snow warning has been issued. The Met Office warns of possible flight delays and cancellations.
Snow will fall as rain moves north-east of England and Wales on Thursday morning in the face of colder air.
It is a very complex climate condition, and can lead to huge differences in conditions depending on how high you are above sea level.
Hills and mountains above 200 meters in Erie – also known as Snowdonia – are likely to receive significant snowfall of between 20 and 25 cm, which could cause disruption.
For example, cross-Penine roads are likely to be closed due to heavy snow.
Away from the higher ground in north Wales and northern England, snow is still possible which could disrupt travel, especially in the morning.
However, the amount of snow here can depend on a number of different factors and may vary over relatively short distances.
For many, although snow is possible temporarily, sleet or sleet will likely mix in the mix.
This will be the case until Thursday afternoon as an area of rain, sleet and snow moves northwards into southern Scotland and Northern Ireland allowing milder air to spread northwards.
In addition to the orange warnings, there are a number of yellow warnings extending from Thursday to Friday.
This includes two yellow snow and ice warnings covering parts of southern Scotland and parts of Northern Ireland, a snow warning covering much of northern England, north Wales and the Midlands, and a rain warning for much of southern England and south Wales.
A separate yellow warning for ice and snow comes into effect at 16:00 on Wednesday until 10:00 on Thursday, covering parts of northern Scotland.
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