At least 41 weather-related deaths have occurred across the United States since Sunday, as the Arctic blast continues to unleash heavy snow and icy temperatures from coast to coast.
In Tennessee alone, the Department of Health confirmed 14 deaths due to the weather.
As of Thursday evening, more than 80 million Americans in 30 states were on alert for cold or snowy weather. The National Weather Service's winter storm warnings and winter weather warnings extend from Montana all the way to the New Jersey shore where a fast-moving storm system is targeting.
While the cold weather was expected to persist across much of the Midwest, temperatures will not be quite as low as they were earlier in the week. However, more snow is expected Thursday as a storm system moves from the Plains into the Midwest and Great Lakes regions, potentially creating dangerous road conditions.
Heavy lake-shaped snow bands are expected to continue in the western part of New York State, while the rest of the Northeast could see some scattered snow showers on Thursday as temperatures remain cold.
Snow will move from Chicago to Cincinnati overnight and into early Friday.
According to the forecast, heavy snow will cover the Ohio Valley, Appalachia and Mid-Atlantic region by 7 a.m. Friday.
Overall, snowfall amounts will likely be minimal, with states like Pennsylvania, New York and New Jersey expected to receive between 1 and 3 inches of snow. The heaviest snow — more than 6 inches — is expected in parts of West Virginia with the Appalachians.
After an unprecedented streak of 701 snow days with less than an inch of snow, New York City could see more than an inch for the second day of this week.
Heavy snow and gusty winds are expected to continue to cause problems in the northwest, especially at higher elevations. Meanwhile, heavy rain will hit much of the West Coast by the end of the week and into the weekend. Heavy snow has fallen on the Rocky Mountains over the past few days, prompting avalanche warnings for several mountains in Colorado.
ABC News' Victoria Arancio, Ahmed Hemingway and Jason Volak contributed to this report.